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Title: 鈥淢echanotransduction through integrins: basic mechanisms and roles in vascular disease鈥�

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Martin Schwartz, PhD

Yale University
Professor of Medicine (Cardiology)
Professor of Biomedical Engineering and of Cell Biology
Hosted by: Dr. Dieter Reinhardt

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Wednesday, Oct 7, 2020 at 11:30 am

Zoom:

Meeting ID: 954 2425 5919

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Cells sense the biochemical and biophysical properties of their extracellular matrix environment through integrin-mediated adhesions. The resultant signals play major roles in guiding development, physiology, and normal tissue remodeling required for homeostasis.听 Conversely, altered integrin-dependent signals contribute to pathological tissue remodeling in cancer, fibrosis, atherosclerosis, and aneurysms.听 I will present our recent work toward understanding fundamental, biophysical mechanisms of force transmission and mechanotransduction through integrins, and the roles of matrix remodeling and integrin signaling in vascular disease.

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