Â鶹AV

Darcy Wagner

Academic title(s): 

Professor, Department of Biomedical Engineering

Professor, Department of Medicine, Division of Experimental Medicine

Canada Excellence Research ChairÌýin Lung Regenerative MedicineÌý

¹ó²¹³¦³Ü±ô³Ù²â,ÌýMeakins-Christie Laboratories ()

Scientist, Translational Research in Respiratory Diseases Program (RESP) at the Research Institute of the Â鶹AV Health Centre ()

Principal Investigator, Â鶹AV Regenerative Medicine Network ()Ìý

Darcy Wagner
Contact Information
Address: 

Research Institute of the Â鶹AV Health Centre

1001 Décarie Blvd., Block E, Montreal, QC, CANADA H4A 3J1

Phone: 
514 934-1934 x76172
Email address: 
darcy.wagner [at] mcgill.ca
Areas of expertise: 

Our lab focuses onÌýhow theÌýextracellular environmentÌýdirectsÌýstem cellÌýbehaviorÌýfor endogenous and exogenous lung tissue regeneration. We use a multidisciplinary approach using advances in materials science (polymer designÌýand synthesis), manufacturing (e.g.Ìý3D bioprinting), andÌýendogenous and iPSC-derived lung stem cellsÌýto construct these new models.Ìý

The main areas of interest of the lab are:Ìý

  • Design and use of biologic (acellular) and synthetic scaffolds in diverse manufacturing approaches to bioengineer new lung tissue for transplantation.Ìý

  • Understand the role of the extracellular matrix in directing lung stem cell behaviour in vivo and ex vivo during regeneration (normal and pathologic)ÌýÌý

  • BuildÌýand validateÌýnew models of human lung tissueÌýand chronic lung diseaseÌýto reduce animal usage and for use as drug discovery and therapeutic screening platforms

°­±ð²â·É´Ç°ù»å²õ:Ìýbioengineering, lung regeneration, biomaterials, stem cells, bioprinting, microfluidics, light sheet fluorescence microscopy, image analysis

Selected publications: 

Recent select publications:

Gvazava et al.ÌýLabel-Free High-Resolution Photothermal Optical Infrared Spectroscopy for Spatiotemporal Chemical Analysis in Fresh, Hydrated Living Tissues and Embryos. Journal of the American Chemical Society.Ìý2023, 145 (45): 24796–24808.

Ptasinski et al.ÌýModeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoids.ÌýLife Science Alliance. 2023, 6(8):e202201853.

Da Silva et al.ÌýFormalin-free fixation and xylene-free tissue processing preserves cell-hydrogel interactions for histological evaluation of 3D calcium alginate tissue engineered constructs.ÌýFront Biomaterial ScienceÌý2023, 2:1155919.

Alsafadi et al.ÌýSimultaneous isolation of proximal and distal lung progenitor cells from individual mice using a 3D printed guide reduces proximal cell contamination of distal lung epithelial cell isolations.ÌýStem Cell RepÌý2022, 17(12): 2718-2731. and

De Santis et al. Extracellular matrix reinforced bioinks for 3D bioprinting human tissue.ÌýAdv MaterialsÌý2021, 33(3):2005476.

Complete Publication List:

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