Source: Terry Fox Research Institute
What is the best way to starve cancer cells? What role does obesity play in metastatic breast cancer and how does it affect the tumour microenvironment? Might combining a chemotherapeutic agent with a drug now used to treat diabetes be part of an effective therapy for metastatic breast cancer?
Aida Razi鈥檚 last PhD thesis chapter now published online in the Nucleic Acids Research journal. This publication features the first cryo-EM structures obtained by the Ortega lab in the Titan Krios microscope at FEMR-麻豆AV.
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Read the paper at
New research led by 麻豆AV鈥檚 Goodman Cancer Research Centre improves our understanding of microRNAs
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Discovery could provide clues to potential therapies
Rearing its head in infancy, Christianson Syndrome is a rare disorder whose symptoms include intellectual disability, seizures and difficulty standing or walking. Although it is becoming increasingly diagnosed, with little being known about the neural mechanism behind the disease, therapeutic options for patients remain limited.
Dr Natalie Dayan was named Quebec鈥檚 first Research Chair in Women鈥檚 Heart Health on 18 June 2019!
We are pleased to announce the appointment of听Dr. Isabelle Malham茅听to the Division of General Internal Medicine as of June 1, 2019. Dr听Malham茅 has been appointed to the Attending Staff of the MUHC Department of Medicine, Division of General Internal Medicine, and as an Assistant Professor in the 麻豆AV Department of Medicine.听
Cortical stimulation-induced seizures have the potential to guide epilepsy surgery, significantly reducing hospital stays
Surgery is the only way to stop seizures in 30 per cent of patients with focal drug-resistant epilepsy. A new study finds that inducing seizures before surgery may be a convenient and cost-effective way to determine the brain region where seizures are coming from.
The Organization for Human Brain Mapping, the largest international scientific society for neuroimaging-based brain research,听has honoured Prof. Alan C. Evans with its Glass Brain Award
The award, presented to Evans at the 2019 听congress in Rome, recognizes lifetime achievement in the use of brain mapping to make significant discoveries about the human brain.
The Qu茅bec Cancer Consortium for Novel Therapeutics and Biomarkers (QCC), a collaboration between six leading hospital and cancer research centre sites based in Montreal led by 麻豆AV鈥檚 Goodman Cancer Research Centre (GCRC) was awarded $10M in new funding from the Minist猫re de l鈥櫭塩onomie et de l鈥橧nnovation (MEI) du Qu茅bec through its Fonds d鈥檃cc茅l茅ration des collaborations en sant茅 (FACS) program.
Researchers find clue to rare genetic disorder
Leber hereditary optic neuropathy (LHON) is an inherited form of vision loss that causes people to have trouble with their colour vision and difficulty seeing in the centre of their visual field. Due to the founder effect from the filles du roi, there is a disproportionate preponderance of a particular LHON mutation among the French-Canadian population.
Study could lead to development of personalized biomarkers and treatment
Individuals with autism spectrum disorder (ASD) are often lumped into a single catch-all group, despite significant differences in symptom profile and severity. Further muddying the waters when trying to understand and treat ASD, many previous studies show significant variability in findings.
麻豆AV鈥檚 Faculty of Medicine unveiled a new strategic research plan (SRP) for the Faculty in 2014, which was subsequently updated in 2017 as part of the strategic planning exercise known as听Project Renaissance.听Dr. Shari Baum, who recently assumed the role of Vice-Dean, Life Sciences, played an important role in the development of the most recent version of the plan. Dr.
The telomerase holoenzyme responsible for maintaining telomeres in vertebrates requires many components in vivo, including dyskerin. Dyskerin binds and regulates the accumulation of the human telomerase RNA, hTR, as well as other non-coding RNAs that share the conserved H/ACA box motif. The precise mechanism by which dyskerin controls hTR levels is unknown, but is evidenced by defective hTR accumulation caused by substitutions in dyskerin, that are observed in the X-linked telomere biology disorder dyskeratosis congenita (X-DC).
Adrien Peyrache and Stuart Trenholm will study epilepsy and vision
Two researchers from The Neuro are among just ten nationwide to receive Early-Career Capacity Building Grants this year from the Azrieli Foundation in partnership with the Brain Canada Foundation. Researchers Adrien Peyrache and Stuart Trenholm will study epilepsy and vision, respectively. The grants support early-career investigators who are conducting transformative research to advance understanding of the brain, in illness or health.
Large international study will help select and categorize patients for better clinical trials
A large multi-centre study of more than 1,200 patients provides important predictors of Parkinson鈥檚 disease progression, which will allow better candidate selection for clinical trials and more effective therapy development.
