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Maryam Tabrizian

Title: 
Professor
Academic title(s): 

Maryam Tabrizian. PhD, MBA | Professor of Biomedical Engineering/Faculty of Medicine and Health Sciences, and Faculty of Dental Medicine and Oral Health Sciences

Canada Research Chair Tier-1 in Regenerative Medicine and Nanomedicine

Editor-in-Chief ‘Materials’ MDPI

Associate Member of Bioengineering &ÌęExperimental Surgery

Maryam Tabrizian
Contact Information
Phone: 
514-398-8129
Email address: 
maryam.tabrizian [at] mcgill.ca
Link(s): 
Biography: 

Maryam TabrizianÌęis Canada Research Chair holder in Regenerative Medicine and Nanomedicine, cross-appointed between Faculty of Medicine-Biomedical Engineering Department and the Faculty of Dental Medicine and Oral Health Sciences. She wasÌęthe founding director of the Centre for Biorecognition and Biosensors (2003-2011) who has received many prestigious awards and fellowships (FRSQ-Chercheure nationale, Guggenheim foundation, Biomaterials Science & Engineering, RSC-Academy of Science, ADEA Leadership Institute, Canadian Academy of Health Sciences,..)Ìęfor herÌęcontributionÌęto the field of Biomedical Engineering and Biomedical Sciences. She hasÌęestablishedÌęexpertise in the design of advanced biomaterials andÌębiointerfacesÌęfor their application in nanomedicine, regenerative medicine and Lab-on-a-chip devices. Professor Tabrizian is the author of over 235 peer-reviewed papers (H-index 63), 110 invited lectures,14 patents, and over 350 communications.

Research Interests

The development of novel interface for improved interaction of biomaterials with biological environment is the overall objective of our research. We aim at building a deeper understanding of cell-biomaterial interactions in order improve our ability to predict and control the host response to new material. This is carried out through design, fabrication and characterization of multifunctional and bioactive surfaces as well as developing methodologies and protocols for creating these new biointerfaces. Our motivation rises from our belief that the future of biomedical devices will exploit materials surfaces that are designed on the basis of engineering principles to mimic the way that nature does it. As such, our laboratory masters a broad expertise in surface modification techniques, namely chemical, molecular assembly and biological methods to cope with the highly divergent requirements for surface properties in biomedical applications. Our target applications are mainly focused on regenerative medicine, nanomedicine and Lab-on-a-Chip platforms.

Examples of our ongoing research activities:

  • Cell-cell and cell-biomaterial interactions.
  • Layer-by-Layer self-assembly as bioactive interface on artificial and biological nanoparticulate templates for imaging, molecular therapy and tissue engineering.
  • 3D and 2D biocompatible hydrogels and sponges for molecular therapy and tissue engineering.
  • Surface molecular engineering and nanopatterning for biorecognition systems
  • Microfluidic platform and Lab-on-a-Chip devices for genomic, proteomic, cell sorting and cell culturing.
  • Non-invasive and real-time assessment of cell and tissue growth in microenvironment Ìę
Areas of expertise: 
  • Biomaterials
  • Biointerface
  • Biorecognition
  • Regenerative medicine
  • Nanomedicine
  • Microfluidics-Lab on a Chip
  • Diagnostic tools
  • Ìę
Courses: 

BME 504 and DENT 504

Research areas: 
Biomaterials, Nanobiotechnology and Tissue Engineering
Awards, honours, and fellowships: 
  • Fellow of Canadian Academy of Health Sciences, 2020
  • Charles P Leblond award recipient, the Network for Oral and Bone Health Research, 2020
  • Canada Research Chair-Tier 1 in regenerative medicine and nanomedicine, 2019
  • American Dental Education Association (ADEA) Leadership Institute Fellow, 2019
  • Member of Europe Science Foundation (ESF): Community of expert, 2019
  • James Âé¶čAV Professor, March 2018
  • Fellow of Royal Society of Canada-Academy of Science, 2017
  • Katz Excellence in Teaching Award, Âé¶čAV, 2017
  • Among the 6 finalists for David Thomson Award for Graduate Supervision and Teaching, 2017
  • International Fellow of the Biomaterials Science & Engineering (FBSE), 2011
  • Guggenheim Follow in Biomedical Sciences, 2010
  • FRQ-S Chercheure nationale (National Researcher Salary Award), 2006-2011
  • FRQ-S-chercheure boursiĂšre (Salary Award), 2001-2006
Selected publications: 

Publications Last 6ÌęYears (Trainee, *Corresponding Author)

196. T. Baudequin, C. Agnes, M. Tabrizian* (2021) "A Core-Shell Guanosine Diphosphate Crosslinked Chitosan Scaffold as a Potential Co-Encapsulation Platform", C, 256, 117499.

195. H. Salmon, M. R. Rasouli, N. Distasio, M. Tabrizian* (2020), “Facile engineering and interfacing of styrenic block copolymers for low-cost, multi-purpose microfluidic devices”, Engineering Reports, Article ID: ENG212361, DOI: 10.1002/eng2.12361.

194. M. Singh, H. Nolan, M. Tabrizian, S. Cosnier, G. S. Duesberg and M. Holzinger* (2020), “Functionalization of contacted Carbon Nanotube Forests by dip coating for high performing bio-cathodes”, , 7(22) .

193. N. Distasio, H. Salmon, F. Dierick, T. Ebrahimian, M. Tabrizian*, S. Lehoux* (September 2020), "VCAM-1 targeted gene delivery nanoparticles localize to inflamed endothelial cells and atherosclerotic plaques", Advanced Therapeutics, .

  1. M. Yafia*, A. M. Foudeh, M. Tabrizian, H. Najjaran (2020), “Low-cost graphene-based digital microfluidic system”, micromachines-904641.

191. M. Yitayew, M. Tabrizian* (2020), "Hollow Microcapsules Through Layer-by-Layer Self-Assembly of Chitosan/Alginate on E. coli", MRS Advances, Cambridge University Press: 22 May 2020, pp. 1-7.

190. K. Jahan, G. Manickam, M. Tabrizian*, M. Murshed* (2020), “In vitro and in vivo investigation of osteogenic properties of self-contained phosphate-releasing injectable purine-crosslinked chitosan-hydroxyapatite construct”, Scientific Reports 10 (1), Article number: 9145.

189. M. Saad, D. Chinerman, M. Tabrizian, S. Faucher* (2020), “Identification of two aptamers binding to Legionella pneumophila with high affinity and specificity”, Scientific Report, Scientific Reports 10, Article number: 9145

188. P. Modarres, M Tabrizian* (2020), “Electrohydrodynamic-Driven Micromixing for the Synthesis of Highly Monodisperse Nanoscale Liposomes”, ACS Appl. Nano Mater. 3(5):4000–4013. .

187. P. Modarres, M Tabrizian* (2020), “Phase-controlled Field-effect Micromixing Using AC Electroosmosis", Microsystems & Nanoengineering (a nature publication) 6, Article number:60 (2020).

186. N. Watcharajittanont, M. Tabrizian, C. Putson, P. Pripatnanont, J. Meesane* (2020) “Osseointegrated membranes based on electro-spun TiO2/hydroxyapatite/poly-urethane for oral maxillofacial surgery”, Mater Sci Eng C Mater Biol Appl, 108:110479.

185. M. Rasouli, M. Tabrizian* (2019), “Ultra-Rapid Acoustic Micromixer for Synthesis of Organic Nanoparticles", Lab Chip 19 (19), 3316 – 3325.

184. F. R. Castiello, J. Porter, P. Modarres, M. Tabrizian* (2019), "Interfacial capacitance immunosensing using interdigitated electrodes: effect of the insulation/immobilization chemistry", Physical Chemistry Chemical Physics, 21, 15787–15797.

183. S. Shoaib, M. Tabrizian* (2019), "A QCM-D biosensing strategy for investigating the real-time effects of oxidative stress on the viscoelastic properties of pre-osteoblast cells", Sensors & Actuators: B. Chemical, 293:235-24615.

182. L. Keller, Y. Idoux-Gillet, P. Schwinté, L. Benameur, M. Tabrizian, P. Auvray, F. Bornert, D. Offner, R. M. Gonzalo-Daganzo, E. Gómez Barrena, N. Benkirane-Jessel* (2019), "Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration", Nature Commun 10(1):2156.

181. S. Chen, A. Auriat, H Ismail, T. Li, A. Galuta, R. Sandarage, R. Wylie, D. X. B. Chen, S. Willerth, M. DeRosa, M. Tarizian, X. Cao, and E. C. Tsai* (2019), “Advancements in Canadian Biomaterials and Implications for Neurotraumatic Diagnosis and Therapies”, Processes,7:336; doi:10.3390/pr7060336.

180. F. R. Castiello, M. Tabrizian* (2019), "Gold nanoparticle amplification strategies for multiplex SPRi-based immunosensing of human pancreatic islet hormones", Analyst, 144(8):2541-2549.

179. P. Modarres, M. Tabrizian* (2019), “Frequency Hopping Dielectrophoresis as a New Approach for Microscale Particle and Cell Enrichment”, Sensors & Actuators: B. Chemical, 286:493-500.

178. K. Jahan, M. Mekhail, M. Tabrizian* (2019), “A one-step fabrication of nanoapatite-chitosan scaffold as a potential soft and injectable construct for bone tissue engineering: An investigation of structural properties”, Carbohydrate Polymers, 203(1):60-70.

177. N. DiStasio, M. Arts, S. Lehoux*, M. Tabrizian* (2018), “IL-10 Gene Transfection in Primary Endothelial Cells via Linear and Branched Poly(b-amino ester) Nanoparticles Attenuates Inflammation in Stimulated Macrophages”, ACS-Appl. Bio Mater. 1(3):917–927.

176. N. Distasio, S. Lehoux, A. Khademhosseini, M. Tabrizian* (2018), ‘The Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research”, Materials 2018, 11, 754; doi:10.3390/ma11050754.

175. R. Castiello, M. Tabrizian* (2018), “Multiplex Surface Plasmon Resonance Imaging-Based Biosensor for Human Pancreatic Islets Hormones Quantification” Anal Chem. 90(5):3132-3139.

174. S. Amrani, M. Tabrizian* (2018), “Passive Encapsulation and Characterization of Nanoscale Liposomes Produced by 2D Hydrodynamic Flow Focusing", ACS Biomater. Sci. Eng., 4(2):502–513.

173. L. Benameur, T. Baudequin, M. Mekhail, M. Tabrizian* (2018), “The Bioconjugation Mechanism of Purine Cross-linkers Affects Microstructure and Cell Response to Ultra Rapidly Gelling Purine-Chitosan Sponges”. Material Chemistry B. 6:602-613.

172. T. Baudequin, M. Tabrizian* (2018), “Multi-lineage Constructs for Scaffold-based Tissue Engineering: A review of Tissue-Specific Challenges”, Adv Healthc Mater. 7(3):1-18.

171. P. Modarres, M. Tabrizian* (2017), “Alternating current dielectrophoresis of biomacromolecules: The interplay of electrokinetic effects”, Sensors and Actuators B: Chemicals, 252:391-408.

170. S. Ghadakzadeh, R. C. Hamdy, M. Tabrizian* (2017), “Efficient in vitro delivery of Noggin siRNA enhances osteoblastogenesis”. Heliyon 3(11):e00450. doi: 10.1016/j.heliyon.

169. F. Melaine, M. Saad, S. Faucher, M. Tabrizian* (2017), “Selective and High Dynamic Range Assay Format for Multiplex Detection of Pathogenic Pseudomonas aeruginosa, Salmonella typhimurium, and Legionella pneumophila RNAs Using Surface Plasmon Resonance Imaging”, Anal Chem. 89(14):7802-7807.

168. K. Heileman, M. Tabrizian* (2017), “Dielectric Spectroscopy Platform to Measure MCF10A Epithelial Cell Aggregation as a Model for Spheroidal Cell Cluster Analysis”, Analyst, 42(9):1601-1607.

167. S. Filion-CĂŽtĂ©, M. Tabrizian, A. G. Kirk* (2017), “Real-Time Measurement of Complex Refractive Indices with Surface Plasmon Resonance”, Sensors and Actuators B: Chemicals, 245:747-752.

166. S. Filion-CĂŽtĂ©, A. G. Kirk, M. Tabrizian* (2017), “Monitoring of Bacterial Film Formation and their Breakdown with an Angular-Based Surface Plasmon Resonance Biosensor”, Analyst, 42(13):2386-2394.

165. L. Nayef, R. Castiello, M. Tabrizian* (2017), “Washless Method Enables Multilayer Coating of an Aggregation-Prone Nanoparticulate Drug Delivery System with Enhanced Yields, Colloidal Stability, and Scalability”. Macromol Biosci. June 17(6). doi: 10.1002/mabi.201600535.

164. K. Heileman, J. Daoud, M. Tabrizian* (2016), “Elaboration of a Finite Element Model of Pancreatic Islet Dielectric Response to Gap Junction Expression and Insulin Release”, Colloids and Surfaces B: Biointerfaces, 148:474–80.

163. O. Felfoul, M. Mohammadi, S. Taherkhani, D. de Lanauze, Y. Zhong Xu, D. Loghin, S. Essa, S. Jancik, D. Houle, M. Lafleur, L. Gaboury, M. Tabrizian, N. Kaou, M. Atkin, T. Vuong, G. Batist, N. Beauchemin, D. Radzioch, S. Martel* (2016), “Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions”, Nature Nanotechnology, 11(11):941-947.

162. E. Samiei, M. Tabrizian, M. Hoorfar* (2016), “A review of digital microfluidics as portable platforms for lab-on a-chip applications”, Lab Chip, 16(13):2376-96.

161. S. Ghadakzadeh, M. Mekhail, A. Aoude, M. Tabrizian*, R. Hamdy* (2016), “Small Players Ruling the Hard Game: siRNA in Bone Regeneration”, J. Bone and Mineral Res., 31(3):475-487.

160. T. Nardo, V. Chiono, P. Gentile, M. Tabrizian, G. Ciardelli* (2016), “Poly(DL-lactide-co-Δ-caprolactone) and poly(DLlactide-co-glycolide) Blends for Biomedical Application: Physical Properties, Cell Compatibility, and in vitro Degradation Behavior, Int J Polymeric Materials and Polymeric Biomaterials, 65(16): 741-750.

159. R. Castiello, K. Heileman, M. Tabrizian* (2016), “Microfluidic perfusion systems for secretomic analysis: applications, challenges and opportunities for pancreatic islet research”, Lab on a Chip, 16:409 - 431.

158. L. Nayef, M. Mekhail, L. Benameur, J. S. Rendon, R. Hamdy, M. Tabrizian* (2016), “A Combinatorial Approach towards Achieving an Injectable, Self-Contained, Phosphate-Releasing Scaffold for Promoting Biomineralization in Critical Size Bone Defects”, Acta Biomaterialia. 1(29):389-97.

157. H. Khadivi Heris, S. Sheibani, J. Daoud, H. Vali, M. Tabrizian*, L. Mongeau* (2016), “Investigation of the Viability, Adhesion, and Migration of Human Fibroblasts in a Hyaluronic acid/Gelatin Microgel-Reinforced Composite Hydrogel for Vocal Fold Tissue Regeneration", Adv Healthcare Materials, 5(2):255-65 (inside front cover Vol. 5. No. 2. January 21. 2016).

156. S. Essa, J. Daoud, M. Lafleur, S. Martel, M. Tabrizian* (2015), "SN-38 active loading in poly(lactic-co-glycolic acid) nanoparticles and assessment of their anticancer properties on COLO-205 human colon adenocarcinoma cells" Journal of Microencapsulation, 32(8):784-93.

155. T. Nardo, V. Chiono, G. Ciardelli, M. Tabrizian* (2015), “PolyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapment on Polytetrafluoroethylene Surface for Application in Periodontal Diseases”, Macromolecular Bioscience, 16(2):288–298.

154. K. Jahan, M. Tabrizian* (2015), “Composite Biopolymers for Bone Regeneration Enhancement in Bony Defects”, Biomater. Sci., 4(1):25-39. (Advance Article).

153. K. Heileman, J. Daoud, C. Hasilo, M. Gasparrini, S. Paraskevas, M. Tabrizian* (2015), “Microfluidic platform for assessing pancreatic islet functionality through dielectric spectroscopy”, Biomicrofluidics, 9, 044125.

152. J. Daoud, K. Heileman, S. Shapka, L. Rosenberg, M. Tabrizian* (2015), “Dielectric Spectroscopy for Monitoring Human Pancreatic Islet Differentiation within Cell-Seeded Scaffolds in a Perfusion Bioreactor System”, Analyst 140, 6295 – 6305.

151. R. Tien Sing Young, M. Tabrizian* (2015), “Rapid, one-step fabrication and loading of nanoscale 1,2-distearoyl-sn-glycero-3-phosphocholine liposomes in a simple, double flow-focusing microfluidic device”, Biomicrofluidics, 9(4):046501.

150. A. Foudeh, H. Trigui, N. Mendis, S. P. Faucher, T. Veres, M. Tabrizian* (2015), “Rapid and Specific SPRi Detection of L. pneumophila in Complex Environmental Water Samples”, Anal Bioanal Chemistry, 407(18):5541-45.

149. M. Singh, M. Holzinger*, M. Tabrizian, S. Winters, N.C. Berner, S. Cosnier*, G. S. Duesberg (2015), “Noncovalently functionalized monolayer graphene for sensitivity enhancement of surface plasmon resonance immunosensors”, J Am Chem Soc. 137(8):2800-3.

148. A. M. Foudeh, D. Brassard, M. Tabrizian, T. Veres* (2015), “Rapid and multiplex detection of Legionella's RNA using digital microfluidics”, Lab on a Chip. 15(6):1609-18.

147. M. Mekhail, G. Almazan, M. Tabrizian* (2015), “Purine-Crosslinked Injectable Sponges Promote Oligodendrocyte Progenitor Cells Attachment and Differentiation”, Biomaterials Science, 3(2), 279-287.

146. M. Singh, M. Holzinger, M. Tabrizian, S. Cosnier* (2015), “Layer by layer scaffold formation using magnetic attraction between HiPCO¼ single-walled carbon nanotubes and magnetic nanoparticles: application for high performance immunosensors” CARBON, 81: 1731 –738.

145. F. Tzelepis, J. Daoud, M. Verway, J. Gillard, K. Hassani-Ardakani, J. Jaworska, Y. NĂ©dĂ©lec, H. Vali, M. Tabrizian, L. Barreiro, M. Divangahi* (2015), “Annexin 1 is critical in immunity to Mycobacterium tuberculosis infection by mediating DC, efferocytosis and antigen cross-presentation”, Journal of Clinical Investigation, 125(2):752-768.

. nih.gov/pmc/articles/PMC4319406/pdf/JCI77014.pdf

144. C. Holmes, M. Tabrizian, P. O. Bagnaninchi* (2015), “Motility imaging via optical coherence phase microscopy enables label-free monitoring of tissue growth and viability in 3D tissue engineering scaffolds", J Tissue Eng and Regenerative Medicine 9(5):641-645.

143. S. Filion-CĂŽtĂ© S, P. J. Roche, A. Foudeh, M. Tabrizian, A. G. Kirk* (2014), “Design and analysis of a spectra-angular surface plasmon resonance biosensor operating in the visible spectrum”, Rev Sci Instrum, 85(9):093107.

142. L. Nayef, J. S. Rendon, R. Matthys, R. C. Hamdy, M. Tabrizian* (2014), “Liposome Encapsulated Quantum Dots Show Efficient In Vivo Retention of a Nanoparticulate Drug Delivery System at its Target in a Rat model of Distraction Osteogenesis”, Journal of Nanopharmaceutics and Drug Delivery, 2(2), 93-102.

141. S. Martel*, S. Taherkhani, M. Tabrizian, M. Mohammadi, D. de Lanauze, O. Felfoul (2014), “Computer 3D Controlled Bacterial Transports and Aggregations of Microbial Adhered Nano-components” Journal of Micro-Bio Robotics, 9():23-28.

140. K. Bowey, J. F. Tanguay, M.G. Sandros, M. Tabrizian* (2014), “Microwave-assisted synthesis of surface-enhanced Raman scattering nanoprobes for cellular sensing”, Colloids Surf B Biointerfaces, 122:617-22.

139. S. Saha, C. Tomaro-Duchesneau, L. Rodes, M. Malhotra, M. Tabrizian and S. Prakash* (2014), “Investigation of probiotic bacteria as dental caries and periodontal disease biotherapeutics”, Beneficial Microbes, 8:1-14.

138. A. M. Makhdom, L. Nayef, M. Tabrizian*, R. C. Hamdy (2014), “The Potential Roles of Nanobiomaterials in Distraction Osteogenesis”, NanoMed-Nanotech Biolog. Med. 11(1):1-18.

137. S. Taherkhani, M. Mohammadi, , S. Martel, M. Tabrizian* (2014), “Covalent Binding of Nanoliposomes to the Surface of Magnetotactic Bacteria for the Synthesis of Self Propelled Therapeutic Agents", ACS Nano, 8(5):5049-60.

136. M. Mekhail, K. Jahan, M. Tabrizian* (2014), “Genipin-crosslinked two-dimensional Chitosan/Poly-L-lysine gels promote Fibroblast adhesion and proliferation”, Carbohydrate Polymers, 108:91-8.

135. M. Mekhail, M. Tabrizian* (2014), “Injectable Chitosan-Based Scaffolds in Regenerative Medicine and their clinical translatability”, Adv Healthcare Materials, 3(10):1529-45.

134. C. Holmes, J. Daoud, P. O. Bagnaninchi, M. Tabrizian* (2014), “Polyelectrolyte multilayer coating of 3D scaffolds enhances tissue growth and gene delivery: Non-invasive and label-free assessment”. Adv Healthcare Materials, 3(4):572–80.

133. K. Bowey, J-F. Tanguay, M. Tabrizian* (2014), “2-Dioleoyl-sn-Glycero-3-Phosphocholine-Based Liposomal Nanoparticles as an Effective Delivery Platform for 17beta-Estradiol”, Eur J Pharmaceutics and Biopharmaceutics, 86(3):369-75.

132. A. M. Foudeh, J. Daoud, S. Faucher, T. Veres, M. Tabrizian* (2014), “Sub-femtomole Detection of 16s rRNA from Legionella pneumophilia Using Surface Plasmon Resonance Imaging Through a Designed Post-amplification Methodology”, Biosensors and Bioelectronics 52:129-35.

131. T. Fatanat Didar, K. Bowey, G. Almazan, M. Tabrizian* (2014), “A miniaturized multipurpose platform for rapid, label-free and simultaneous separation, patterning and in vitro culture of primary and rare cells”, Adv Healthcare Materials, 3(2):253-60.

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