Peter Metrakos
Professor of Surgery, Pathology and Anatomy and Cell Biology
Research: Liver physiology, pathology and molecular signatures. Non-alcoholic fatty liver disease (NAFLD) is now the leading cause of liver disease in North America and can lead to Type II diabetes, liver cirrhosis (requiring liver transplantation), liver cancer (hepatocellular cancer, ) and increase the probability of other types of cancer spreading to the liver (liver metastasis). With the help of our human tissue bank and technologies such as proteomics and genomics, we hope to find new therapies for these diseases
Expertise: liver metastasis; liver ischemia/reperfusion injury; non-alcoholic liver disease; hepatocellullar carcinoma; neuroendocrine tumors; proteomics; tissue banking
1: Alamri H, Patterson NH, Yang E, Zoroquiain P, Lazaris A, Chaurand P, Metrakos
P. Mapping the triglyceride distribution in NAFLD human liver by MALDI imaging
mass spectrometry reveals molecular differences in micro and macro steatosis.
Anal Bioanal Chem. 2018 Dec 5. doi: 10.1007/s00216-018-1506-8. [Epub ahead of
print] PubMed PMID: 30515538.
2: Chen YI, Miller CS, Hashim A, Valenti D, Metrakos P, Barkun J, Zogopoulos G,
Barkun AN, Bessissow A. EUS-IR-Guided Revision of Whipple Anatomy for Concomitant
Afferent and Efferent Limb Obstruction. Am J Gastroenterol. 2018
Dec;113(12):1747. doi: 10.1038/s41395-018-0411-2. Epub 2018 Nov 21. PubMed PMID:
30464305.
3: Barkati S, Gottstein B, Mu Ller N, Sheitoyan-Pesant C, Metrakos P, Chen T,
Garceau R, Libman MD, Ndao M, Yansouni CP. First Human Case of Metacestode
Infection Caused by Versteria sp. in a Kidney Transplant Recipient. Clin Infect
Dis. 2018 Sep 13. doi: 10.1093/cid/ciy602. [Epub ahead of print] PubMed PMID:
30212859.
4: Lazaris A, Amri A, Petrillo SK, Zoroquiain P, Ibrahim N, Salman A, Gao ZH,
Vermeulen PB, Metrakos P. Vascularization of colorectal carcinoma liver
metastasis: insight into stratification of patients for anti-angiogenic
therapies. J Pathol Clin Res. 2018 Jul;4(3):184-192. doi: 10.1002/cjp2.100. Epub
2018 Apr 14. PubMed PMID: 29654716; PubMed Central PMCID: PMC6065118.
5: Hashim A, Chen YI, Valenti D, Metrakos P, White S, Barkun A, Bessissow A.
Endosonography-guided hepatogastrostomy post-percutaneous biliary drainage in
collaboration with interventional radiology. Endoscopy. 2018 May;50(5):E115-E116.
doi: 10.1055/s-0044-101252. Epub 2018 Feb 16. PubMed PMID: 29452431.
6: van Dam PJ, van der Stok EP, Teuwen LA, Van den Eynden GG, Illemann M,
Frentzas S, Majeed AW, Eefsen RL, Coebergh van den Braak RRJ, Lazaris A,
Fernandez MC, Galjart B, Laerum OD, Rayes R, Gr眉nhagen DJ, Van de Paer M, Sucaet
Y, Mudhar HS, Schvimer M, Nystr枚m H, Kockx M, Bird NC, Vidal-Vanaclocha F,
Metrakos P, Simoneau E, Verhoef C, Dirix LY, Van Laere S, Gao ZH, Brodt P,
Reynolds AR, Vermeulen PB. International consensus guidelines for scoring the
histopathological growth patterns of liver metastasis. Br J Cancer. 2017 Nov
7;117(10):1427-1441. doi: 10.1038/bjc.2017.334. Epub 2017 Oct 5. PubMed PMID:
28982110; PubMed Central PMCID: PMC5680474.
7: Simoneau E, Chicoine J, Negi S, Salman A, Lazaris A, Hassanain M, Beauchemin
N, Petrillo S, Valenti D, Amre R, Metrakos P. Next generation sequencing of
progressive colorectal liver metastases after portal vein embolization. Clin Exp
Metastasis. 2017 Jun;34(5):351-361. doi: 10.1007/s10585-017-9855-9. Epub 2017 Jul
31. PubMed PMID: 28758175.
8: Molla NW, Hassanain MM, Fadel Z, Boucher LM, Madkhali A, Altahan RM, Alrijraji
EA, Simoneau EB, Alamri H, Salman A, Gao Z, Metrakos PP. Effect of non-alcoholic
liver disease on recurrence rate and liver regeneration after liver resection for
colorectal liver metastases. Curr Oncol. 2017 Jun;24(3):e233-e243. doi:
10.3747/co.24.3133. Epub 2017 Jun 27. PubMed PMID: 28680292; PubMed Central
PMCID: PMC5486397.
9: Metrakos P, Nilsson T. Non-alcoholic fatty liver disease--a chronic disease of
the 21<sup>st</sup> century. J Biomed Res. 2018 Sep 29;32(5):327-335. doi:
10.7555/JBR.31.20160153. PubMed PMID: 28550272; PubMed Central PMCID: PMC6163117.
10: Cassinotto C, Dohan A, Gallix B, Simoneau E, Boucher LM, Metrakos P, Cabrera
T, Torres C, Muchantef K, Valenti DA. Portal Vein Embolization in the Setting of
Staged Hepatectomy with Preservation of Segment IV 卤 I Only for Bilobar
Colorectal Liver Metastases: Safety, Efficacy, and Clinical Outcomes. J Vasc
Interv Radiol. 2017 Jul;28(7):963-970. doi: 10.1016/j.jvir.2017.01.001. Epub 2017
Mar 7. PubMed PMID: 28283401.
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