麻豆AV

狈补尘别:听James Renaud

Level at MPU:听Postdoc

贰尘补颈濒:听james.renaud [at] mail.mcgill.ca

Website:

厂耻辫别谤惫颈蝉辞谤(蝉):听Dr. Jan Seuntjens

Research interests:听Radiation therapy physics,听Radiation dosimetry, Calorimetry

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Research summary

The goal of radiotherapy is to treat cancer by delivering a prescribed radiation dose to a target volume while limiting the dose to healthy tissues. The accuracy to which the prescribed dose can be delivered and the level to which normal tissues can be spared depend on the accuracy to which the dose (energy deposited per unit mass) can be determined for a given treatment. There are several steps involved in determining the dose, including the transfer of dosimeter calibration factors from a standards lab to the clinic, and relative measurements under non-reference conditions based on a reference dose. The proposed research focuses on developing two calorimetry-based dosimetry systems to improve the accuracy of these steps. Calorimetry-based detectors are unique in that no radiation is required for calibration and thus offer the most direct means to measure dose.

The first of these systems is a miniaturized probe-format graphite calorimeter, the first ever absolute dosimeter designed for routine clinical application (Patent No. PCT/CA2013/000523). Calorimeters have been used as primary standards for decades, however they have always been too bulky and fragile for clinical use. With a series of functioning prototypes built and a proof-of-concept completed, the current aim of our work is to apply this technology to MR-guided radiotherapy, an area which is proving to be problematic for conventional dosimeters.

We are also developing a cutting edge water calorimeter as a prototype dosimetry standard for ion beam radiation. Ion beams (e.g., proton, carbon ion) have gained considerable interest because of their sharp penumbrae and distal dose fall off combined with an increased relative biological effectiveness. This project consists of a numerical design optimization study modeling the dosimetric responses of the calorimeter to ion radiation, followed by experimental validation studies in a proton and carbon ion beam. Experimental collaborators include the Clatterbridge Cancer Centre (UK), National Physical Laboratory (UK), Universit茅 Catholique de Louvain (Belgium) and Gunma University Heavy Ion Medical Center (Japan).

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Key publications

1. Renaud J, Sarfehnia A, Bancheri J,听et al., "Aerrow: A probe-format graphite calorimeter for use as a local absorbed dose standard for clinical high-energy photon and electron beams," Med. Phys., 2016.听[Submitted]
2. Louren莽o A, Thomas R, Homer M,听et al., 鈥淔luence correction factor for graphite calorimetry in a clinical high-energy carbon-ion beam,鈥� Phys. Med. Biol., 2016 [Submitted]
3. Renaud J, Rossomme S, Sarfehnia A, et al., "Development and application of a water calorimeter for short-range particle beams," Phys. Med. Biol., 2016.听dx.doi.org/10.1088/0031-9155/61/18/6602
4. Renaud J, Sarfehnia A, Marchant K, et al., 鈥淒irect measurement of electron beam quality conversion factors using water calorimetry,鈥� Med. Phys., 2015,听dx.doi.org/10.1118/1.4931970
5. Renaud J, Marchington D, Seuntjens J, et al., 鈥淒evelopment of a graphite probe calorimeter for absolute clinical dosimetry,鈥� Med. Phys., 2013;40(2): Medical Physics Letter, 020701-1,听dx.doi.org/10.1118/1.4773870
6. Renaud J, Sarfehnia A, Seuntjens J, Method and system for calorimetry probe, PCT International Publication Number WO 2013/1777677, filed May 2013,听patentscope.wipo.int/search/en/WO2013177677.
7. Martin S, Rodrigues G, Chen Q, et al., 鈥淓valuation of tomotherapy MVCT image enhancement program for tumor volume delineation,鈥� J. Appl. Clin. Med. Phys., 2011;12(3):112-121,听dx.doi.org/10.1120/jacmp.v12i3.3505
8. Renaud J, Yartsev S, Dar AR, et al., 鈥淪uccessful treatment of primary renal lymphoma using image guided helical TomoTherapy,鈥� Can. J. Urol., 2009;16(3):4639-4647.听PMID: 19497170
9. Renaud J, Yartsev S, Dar AR, et al., 鈥淎daptive radiation therapy for localized mesothelioma with mediastinal metastasis using helical tomotherapy,鈥� Med. Dosim., 2009;34(3):233-242,听dx.doi.org/10.1016/j.meddos.2008.10.002

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Awards

(2016) NSERC Idea to Innovation (I2I) Grant - Phase I

(2016) 1st Prize, 麻豆AV Dobson Cup Start Up Competition (Health Sciences track)

(2016) AAPM Science Council Associates Mentorship Program听

(2015) Schulich Graduate Fellowship in Physics

(2015)听The Terry Fox Foundation Strategic Training Initiative for Excellence in Radiation Research for the 21st Century (EIRR21) Scholar

(2012-2015) CIHR Graduate Scholarship Doctoral Award (CGS D)

(2014) Sylvia Fedoruk Prize

(2012 & 2015) J.R. Cunningham Young Investigator Runner-up

(2014) Reginald Fessenden Prize in Science Innovation

(2011) NSERC Canada Graduate Scholarship (CGS M)

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