Â鶹AV

In vertebrates, the response elicited by invading pathogens involves a sophisticated interplay of cells that constitute the innate and adaptive immune systems. This concerted response – precise in its quality, magnitude and duration – is fundamental for the elimination or control of infectious agents and the repair of the affected tissue/organ. Imprecision in the response can have serious deleterious consequences including damage to host tissue or failure to eliminate the pathogen. I will present our discoveries on key biochemical checkpoints in the innate immune system that define the activation threshold and intensity of the consequent antigen-specific adaptive immune responses. I will also discuss how these checkpoints trigger the resolution of inflammation and induction of tissue repair.

This seminar will be given online via Zoom. Details in attached poster.

This event is co-sponsored by the Â鶹AV Department of Microbiology and Immunology.