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J. Lowell Orbison Endowed Chair; Professor of Biochemistry & Biophysics; Professor of Oncology, School of Medicine and Dentistry; Director, Center for RNA Biology: From Genome to Therapeutics; and Chair of Graduate Women in Science, University of Rochester.

Winner of the 2015 Canada Gairdner International Award for the discovery of the mechanism that destroys mutant messenger RNAs in human cells, nonsense-mediated mRNA decay, which is critically important in both normal and disease states.

Professor Maquat is known for her mammalian-cells studies of nonsense-mediated messenger RNA decay, which she first reported in 1981 through studies of the hemolytic anemia bo-thalassemia and from which she subsequently discovered the pioneer round of translation, the exon-junction complex (EJC), and how the EJC marks mRNAs for a first quality-control translation cycle that largely occurs as newly synthesized messenger RNAs enter the cytoplasm. She continues to make seminal contributions on mechanisms of NMD and another pathway she discovered and named Staufen-mediated mRNA decay (SMD).

Professor Maquat is an elected Fellow of the American Association for the Advancement of Science (2006), an elected Member of the American Academy of Arts and Sciences (2006) and the National Academy of Sciences (2011), and a Batsheva de Rothschild Fellow of the Israel Academy of Sciences and Humanities (2012). Professor Maquat was awarded the William C. Rose Award from the American Society for Biochemistry and Molecular Biology (2014) for research and mentoring, in particular advocacy for women in science.

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Founder & CEO, Google DeepMind; AlphaFold Project Lead

Winner of the 2023 Canada Gairdner International Award for developing AlphaFold, which has been heralded as an AI-based solution to the 50-year grand challenge of protein structure prediction and has culminated in the release of the most accurate and complete picture of the structure of the human proteome, with enormous potential to accelerate biological and medical research.

Demis Hassabis is the Founder and CEO of DeepMind, the world鈥檚 leading AI research company, and now a part of Alphabet. Founded in 2010, DeepMind has been at the forefront of the field ever since, producing landmark research breakthroughs such as AlphaGo, the first program to beat the world champion at the complex game of Go, and AlphaFold, which was heralded as a solution to the 50-year grand challenge of protein folding.

His work has been cited over 100,000 times and has been featured in Science鈥檚 top 10 Breakthroughs of the Year on 4 separate occasions. He is a Fellow of the Royal Society and the Royal Academy of Engineering. In 2017 he featured in the Time 100 list of most influential people, and in 2018 he was awarded a CBE.