Available Positions:
Postdoctoral Fellow Positions -Â Synthetic Biology
Open research positions in the lab of Professor Codruta Ignea
Start date:Â immediate/rolling
The Synthetic Biology group (Prof. Codruta Ignea) in the Bioengineering department at the Â鶹AV invites highly motivated candidates to apply for a Postdoctoral Researcher position to study terpenoid biosynthesis and production using microbial cell factories.
Our group focus on the production of bioactive compounds in engineered yeast targeting the largest class of natural products, the terpenoids. These compounds have found various applications as pharmaceuticals, food supplements, flavors and fragrances, biopesticides or even biofuels. By reconstructing and optimizing target pathways and enzymes involved in terpenoid biosynthesis, we aim to achieve high yields of known compounds and produce new-to-nature molecules with potential interesting activities.
Project description: A talented postdoctoral researcher is needed in Dr. Codruta Ignea’s research lab in the Bioengineering department at Â鶹AV to work on an interdisciplinary project for the production of bioactive terpenoids in yeast cells. The project is part of an integrative program aiming to AI-driven discovery of small molecules for drug development and combines computational studies with synthetic biology, metabolic engineering and bioactivity evaluation. The project involves synthetic biology, metabolic engineering and genome editing approaches for the reconstruction and optimization of target biosynthetic pathways in yeast cells, gene mining and screening of library candidates, enzyme engineering, production and characterization of target compounds.
²Ï³Ü²¹±ô¾±´Ú¾±³¦²¹³Ù¾±´Ç²Ô²õ:ÌýApplicants must hold a Ph.D. in biochemistry or molecular biology (or a related discipline) with experience in biochemical engineering, enzymology, and/or analytical chemistry. Experience and good experimental skills in molecular techniques, protein engineering and mass spectrometry or computational skills on genomics/transcriptomics, enzyme structure or protein-protein networks are an advantage. Knowledge about plant natural products, specialized metabolism, or yeast manipulation is desirable but not essential.
How to apply: Please send an application package containing a cover letter including a short description of relevant expertise, an up-to-date CV and the contact details of two references by clicking .Ìý