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Daniel J. Bernard, Ph.D. Professor, Department of Pharmacology and Therapeutics Tel: 514-398-2525 daniel.bernard [at] mcgill.ca 听 |
Biographical Sketch
Prof. Bernard earned his Ph.D. at Johns Hopkins University and then conducted post-doctoral research in molecular endocrinology at Northwestern University. His first independent position was as a Staff Scientist at the Population Council鈥檚 Center for Biomedical Research at The Rockefeller University. He then moved his lab to 麻豆AV in April 2006.听听
Keywords
Pituitary, neuroendocrinology, reproductive biology, signal transduction, transcription, mouse genetics, cell culture听
Research or Clinical Activities
The听Bernard听lab investigates molecular mechanisms of pituitary hormone synthesis and action using in vitro and in vivo approaches. Projects in the lab concern: 1) signal transduction mechanisms through which members of the transforming growth factor 尾 superfamily regulate pituitary follicle-stimulating hormone (FSH) synthesis, 2) mechanisms of gonadotropin-releasing hormone (GnRH) signaling in pituitary gonadotrope cells, 3) extragonadal actions of FSH, and 4) hypothalamic-pituitary control of thyroid hormone production.
Selected Recent Publications
Sun Y, Bak B, Schoenmakers N, van Trotsenburg AS, Oostdijk W, Voshol P, Cambridge E, White JK, le Tissier P, Gharavy SN, Martinez-Barbera JP, Stokvis-Brantsma WH, Vulsma T, Kempers MJ, Persani L, Campi I, Bonomi M, Beck-Peccoz P, Zhu H, Davis TM, Hokken-Koelega AC, Del Blanco DG, Rangasami JJ, Ruivenkamp CA, Laros JF, Kriek M, Kant SG, Bosch CA, Biermasz NR, Appelman-Dijkstra NM, Corssmit EP, Hovens GC, Pereira AM, Dunnen JT, Wade MG, Breuning MH, Hennekam RC, Chatterjee K, Dattani MT, Wit JM,听Bernard听DJ听(2012)听听Nature Genetics听44(12):1375-1381.听
Toufaily C, Fortin J, Alonso CAI, Lapointe E, Zhou X, Santiago-Andres Y, Lin Y-F,听Cui Y,听Wang Y, Devost D, Roelfsema F, Steyn F, Hanyaloglu AC, H茅bert TE, Fiordelisio T, Boerboom D,听Bernard听DJ听(2021)听听eLife,听10:e72937.
Ruf-Zamojski F, Zhang Z, Zamojski, Smith GR, Mendelev N, Liu H, Nudelman G, Moriwaki M, Pincas H, Castanon RG, Nair VD, Seenarine N, Amper MAS, Zhou X, Ongaro L, Toufaily C, Schang G, Nery JR, Bartlett A, Aldridge A, Jain N, Childs GV, Troyanskaya OG, Ecker JR, Turgeon JL, Welt CK,听Bernard听DJ, Sealfon SC (2021) 听Nature Communications听12:听2677.
Br没l茅 E, Wang Y, Li Y, Lin Y-F, Zhou X, Ongaro L, Alonso CAI, Buddle ERS, Schneyer AL, Byeon C-H, Hinck CS, Mendelev N, Russell JP, Cowan M, Boehm U, Ruf-Zamojski F, Zamojski M, Andoniadou CL, Sealfon SC, Harrison CA, Walton KL, Hinck AP,听Bernard听DJ听(2021) 听Science Advances听7(51): eabl4391.听