Amyloid-beta and tau proteins have long been associated with Alzheimerās disease. The pathological buildup of these proteins leads to cognitive decline in people with the disease. How it does that, though, remains poorly understood.ĢżĢż
A new study from the labs of Sylvain Baillet at The Neuro and Sylvia Villeneuve at the Douglas Research Centre provides important insight into how these proteins impact brain activity and possibly contribute to cognitive decline.ĢżĢż
The team led by Jonathan Gallego Rudolf, a Ph.D. candidate in Baillet and Villeneuveās labs, recruited 104 people with a family history of Alzheimerās. They scanned the participantsā brains using a combination of positron emission tomography (PET) to detect the presence and location of the proteins and magnetoencephalography (MEG) to record brain activity in these regions.ĢżĢż
The scientists compared the results of the two scans and found that brain areas with increased levels of amyloid-beta showed macroscopic expressions of brain hyperactivity, reflected by increased fast- and decreased slow-frequency brain activity. For people with both amyloid-beta and tau in their brain, the pattern shifted towards hypoactivity, with higher levels of pathology leading to brain activity slowing.ĢżĢż
Using cognitive tests performed about four years after the brain scans, the team discovered that participants with higher rates of this amyloid-tau related brain slowing showed higher levels of decline in attention and memory.Ģż
The findings suggest that the interplay between amyloid-beta and tau lead to altered brain activity before noticeable cognitive symptoms appear. In a follow up study, Rudolf plans to rescan the same participants over time to prove whether the accumulation of the two proteins promotes further slowing of brain activity, and whether this accurately predicts the cognitive evolution of the participants.ĢżĢż
āOur study provides direct evidence in humans for the hypothesized shift in neurophysiological activity, from neural hyper- to hypo-activity, and its association with longitudinal cognitive decline. These results parallel findings from animal and computational models and contribute to the advancement of our understanding of the pathological mechanisms underlying the preclinical stage of Alzheimerās disease,ā says Rudolf.ĢżĢż
Their findings in a paper titled āSynergistic association of AĪ² and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adultsā in the journal Nature Neuroscience on Sept. 18, 2024.Ģż
