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Killam Seminar Series: Microfluidic tools for studying cell-cell interactions

Mardi, 20 ´Úé±¹°ù¾±±ð°ù, 2024 16:00à17:00
Montreal Neurological Institute de Grandpre Communications Centre, 3801 rue University, Montreal, QC, H3A 2B4, CA

Grâce à la générosité des fiducies Killam, Le Neuro convoque lors d’une série de séminaires des conférenciers d’exception dont les travaux passionnent ses chercheurs et ceux de l’Université Â鶹AV.Ìý


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Iain Clark

Professeur adjoint, bio-ingénierie, UC Berkeley, États-Unis

±áô³Ù±ð:Ìýjo.stratton [at] mcgill.ca (Jo Anne Stratton)

Abstract:ÌýCentral nervous system (CNS)-resident astrocytes and microglia interact to regulate pro-inflammatory programs that drive neurodegenerative diseases, but the pathways and molecules involved are largely unknown. Understanding the language of inflammation is a central question in the field of Neuroimmunology and may guide new therapeutic approaches for multiple sclerosis (MS) and other neurologic diseases. Interactions between CNS-resident cells are highly heterogeneous; astrocytes and microglia nourish and protect neurons, while inflammatory subsets drive demyelination and neurodegeneration in neurologic diseases. We recently developed two novel approaches to study astrocyte-microglia interactions at the single-cell level during inflammation: 1) an in vivo barcoding-based strategy that analyzes the transcriptomes and connections between individual cells, and 2) a droplet-based platform for genome-wide, unbiased CRISPR/Cas9 screening of genes that mediate cell crosstalk. In this seminar, I will discuss the development of these technologies and their application to study astrocyte-microglia signaling in experimental autoimmune encephalomyelitis (EAE), a preclinical mouse model of MS.

Le NeuroÌýÂ鶹AV

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Le Neuro (L'Institut-Hôpital neurologiqueÌýde Montréal) - un institut de recherche et d’enseignement bilingue de Â鶹AV, qui offre des soins de haut calibre aux patients - est la pierre angulaire de la Mission en neurosciences du Centre universitaire de santé Â鶹AV. Nous sommes fiers d’être une institution Killam, soutenue par les fiducies Killam.

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