Claudio Cuello
Charles E Frosst Endowed Chair in Pharmacology & Therapeutics
Research Interests
My main goals and objectives at present are to continue leading an outstanding research team in its work on multidisciplinary aspects of aging, developing more advanced models of Alzheimer'sÌýdisease (AD) neuropathology, investigating early CNS inflammation in AD pathology, degeneration and the study of repair and therapeutics of the AD pathology.
While pursuing these objectives, I continue to collaborate with colleagues on pain-related issues in which I have a historical interest. Some of my earliest work was on the transmitter/modulatory role of neuropeptides, demonstrating the vesicular storage of substance P, its presence in central and peripheral (dendritic) branches of primary sensory neurons, the participation of substance P in antidromic vasodilation, and the distribution of substance P in defined pathways in the CNS of experimental animals and in the human brain.
More recently, I have collaborations with the group of Dr. Alfredo Ribeiro-Da-Silva regarding the role of NGF metabolic pathway in pain mechanisms and in therapeutic opportunities. Likewise, we have collaborated with the group of Dr. Laura Stone for pain related epigenetic mechanisms.
Expertise
Dr. A. Claudio Cuello is a Professor of Pharmacology at Â鶹AV in Montreal, Canada, and presently holds the Charles E. Frosst Merck Endowed Chair in Pharmacology and Therapeutics. He was the Department's Chair from 1985 to 2000. He is presently an Associate Member of the Â鶹AV Departments of Anatomy & Cell Biology, and of Neurology & Neurosurgery, and has been recently named Adjunct Professor, Department of Neuropharmacology, at the Scripps Institute in La Jolla, California. He is a past Staff Scientist for the Medical Research Council in Cambridge, U.K. (1975-1978), Lecturer (Associate Professor) in Neuropharmacology and Neuroanatomy at Oxford University and Fellow and Medical Tutor at Lincoln College, Oxford (1978-1985). Named Highly Cited Neuroscientist by the Institute for Scientific Information, his full biography has been published in The History of Neuroscience in Autobiography (ed. Larry R. Squire, Academic Press, NY, 2001).
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